ミュラー管の発生の発生はまだその全貌が明らかにされてはいないようです。しかし、
Cellular mechanisms of Müllerian duct formation in the mouse Grant D. Orvis, Richard R. Behringer Developmental Biology Volume 306, Issue 2, 15 June 2007, Pages 493-504 Developmental Biology https://www.sciencedirect.com/science/article/pii/S001216060700228X?via%3Dihub
に詳し解析があります。
- In the first phase, cells of the coelomic epithelium are specified to a Müllerian duct fate through an unknown mechanism. This specification can be identified by the expression of Lim1 in cells of the coelomic epithelium (Kobayashi et al., 2004).
- After specification, Wnt4 expression from the mesonephros or coelomic epithelium, induces the invagination of these specified cells (Kobayashi et al., 2004, Vainio et al., 1999).
- when the Wolffian duct is disrupted at a specific point in ovo, the Müllerian duct is unable to grow past that point (Gruenwald, 1937).
https://www.sciencedirect.com/science/article/pii/S001216060700228X?via%3Dihub