月別アーカイブ: 2021年1月

トリプルネガティブタイプの乳がん(Triple Negative Breast Cancer; TNBC)について


  1. Triple-Negative Breast Cancer cdc.gov
  2. A New Way to Fight Triple-Negative Breast Cancer Arrives March 3, 2021 Kristie L. Kahl   curetoday.com
  3. Treating Triple-Negative Breast Cancer: Recent Progress and What’s to Come Several sessions at SABCS highlighted our gains against this aggressive form of breast cancer—and the challenges that still remain By BCRF | January 20, 2021 BCRF. Ninety-five percent of newly diagnosed TNBC patients have early-stage disease, and based on recent clinical trial results, their five-year disease-free survival is well over 80 percent.
  4. Update on Strategies to Improve Treatment for Triple Negative Breast Cancer Keytruda, Tecentriq, and Sacituzumab Govitecan (IMMU-132) are promising TNBC treatment advances. CANCERCONNECTDEC 11, 2020
  5. Treatment of Triple-negative Breast Cancer (cancer.org) chemotherapy (chemo) is the main systemic treatment option. And although TNBC tends to respond well to initial chemo, it tends to come back (recur) more frequently than other breast cancers.
  6. Triple-Negative Breast Cancer breastcancer.org



IMpassion031 is a phase III trial in patients with early-stage TNBC testing the safety and effectiveness of the checkpoint inhibitor atezolizumab used in tandem with standard chemotherapy prior to surgery (called neoadjuvant therapy). ‥ IMpassion031 involved 333 newly diagnosed patients with TNBC who were randomly assigned to receive either atezolizumab plus chemotherapy (nab-paclitaxel, doxorubicin, or cyclophosphamide) or the same chemotherapy agents plus a placebo prior to undergoing breast cancer surgery.


  1. Trial finds benefit of immunotherapy-chemotherapy combination in early-stage triple-negative breast cancer



  1. Effect of Adjuvant Paclitaxel and Carboplatin on Survival in Women With Triple-Negative Breast Cancer A Phase 3 Randomized Clinical Trial Ke-Da Yu, MD, PhD1; Fu-Gui Ye, MD1; Min He, MD1; et al JAMA Oncol. 2020;6(9):1390-1396. doi:10.1001/jamaoncol.2020.2965 August 13, 2020



  1. Immunotherapy in Triple-Negative Breast Cancer: How to Move Forward October 1, 2020 Carlos H. dos Anjos, MD, and Romualdo Barroso-Sousa, MD, PhD ASCO Daily News. Immune checkpoint blockade (ICB) has revolutionized the treatment of early and advanced solid tumors, including triple-negative breast cancer (TNBC), especially when combined with cytotoxic chemotherapy. Only a fraction of patients with TNBC benefit from ICB plus cytotoxic chemotherapy, so biomarkers to predict a response are urgently needed, with emphasis on composite biomarkers.



  1. Multidisciplinary considerations in the treatment of triple‐negative breast cancer.  Jennifer R. Bellon MD Harold J. Burstein MD, PhD Elizabeth S. Frank EdM Elizabeth A. Mittendorf MD, PhD Tari A. King MD First published: 28 September 2020 https://doi.org/10.3322/caac.21643 A Cancer Journal of Clinicians



  1. A Strategy to Fight against Triple-Negative Breast Cancer: pH-Responsive Hexahistidine-Metal Assemblies with High-Payload Drugs Long Zhang, Hongyan Xu, Xiaoxiao Wu, Wenjuan Huang, Tinghong Zhang, Pengyan Hao, Bo Peng*, and Xingjie Zan* Cite this: ACS Appl. Bio Mater. 2020, 3, 8, 5331–5341 Publication Date:July 7, 2020 https://doi.org/10.1021/acsabm.0c00653 TNBC has the highest rate of metastatic disease and the poorest overall five-year survival rate (less than 25% for TNBC) compared to other breast cancer subtypes (90.3 and 92.5% for ER+PR+/HER2+ and ER+PR+/HER2, respectively).



  1. Most neoadjuvant chemotherapy for triple-negative breast cancer should include platinum. Rebecca Dent Hope S Rugo Published:January, 2021DOI:https://doi.org/10.1016/S1470-2045(20)30747-6 THE LANCET Oncology PERSPECTIVES|SPOTLIGHT| VOLUME 22, ISSUE 1, P27-28, JANUARY 01, 2021
  2. Practical classification of triple-negative breast cancer: intratumoral heterogeneity, mechanisms of drug resistance, and novel therapies. Antonio Marra, Dario Trapani, Giulia Viale, Carmen Criscitiello & Giuseppe Curigliano npj Breast Cancer volume 6, Article number: 54 (2020) Published: 16 October 2020
  3. Emerging CAR-T Cell Therapy for the Treatment of Triple-Negative Breast Cancer Sundee Dees, Rajkumar Ganesan, Sanjaya Singh and Iqbal S. Grewal DOI: 10.1158/1535-7163.MCT-20-0385 Published December 2020 Molecular Cancer Therapeutics
  4. A Review of Natural Therapies Potentially Relevant in Triple Negative Breast Cancer Aimed at Targeting Cancer Cell Vulnerabilitie. Myfanwy Jane Webb, BScHons, PhD, Craig Kukard, MBChB, MMed, FRACP Craig Kukard University of Newcastle, Newcastle, NSW, Australia See all articles by this author Search Google Scholar for this author First Published November 27, 2020 Review Article https://doi.org/10.1177/1534735420975861
  5. Triple-negative breast cancer molecular subtyping and treatment progress. Li Yin, Jiang-Jie Duan, Xiu-Wu Bian & Shi-cang Yu Breast Cancer Research volume 22, Article number: 61 (2020) Published: 09 June 2020



  1. Triple-Negative Breast: Cancer Pat Prijatel, diagnosed with early-stage triple-negative breast cancer in May 2006 and author of Surviving Triple Negative Breast Cancer, discusses what that diagnosis has meant to her; why she started her blog, Positives About Negative; and advice she would give a person newly diagnosed.(インタビュー音声22:58 breastcancer.org)




  1. 「あのとき信じなければ」小林麻央さんも後悔 がんを見落とす医者 体験者たちが語る無念の実例(2017.07.16 週刊現代)麻央さんが初めてがんを意識したのは、’14年2月。夫の市川海老蔵と人間ドックを受け、医師にこう告げられた。「左乳房に腫瘤があります。これはしっかり検査して診てもらったほうがいいので、なるべく早く病院へ行ってください」 麻央さんが「がんの可能性もあるということですか」と尋ねると、「五分五分です」この段階で、がんのリスクはハッキリと麻央さんに提示されていた。しかしその直後、麻央さんは都内の虎の門病院で、マンモグラフィ検査などを受け、がんを疑う状況ではないと告げられる。



  1. 若年乳癌(厚生労働省)乳がん患者さんの年齢分布は図1のようになりました。40〜50歳代の患者さんが最も多く、平均年齢は57.4歳でした。この中で35歳未満の若年性乳がんはわずかに約2.7%でした(図2)。



  1. 25歳で乳がんを患った元SKE48が真剣に考えた「妊孕性」について 卵子凍結、乳房再建、そして… (2019.12.23 現代ビジネス)元SKE48の矢方美紀さんは、25歳で乳がんの宣告を受けた。… 『27歳のニューガンダイアリー』が『コミックDAYS』にて連載中 … 左胸に石のような固いものがあるのに気づいて……。その時は、まさかがんとは思わず、『そのうち消えるだろう』なんて軽く考えていたんですが1週間たってもまだ消えていない。



  1. 乳がんは早期発見で治癒できるって知ってますか!?(2017.02.11 乳がんのブログ)
  2. AYA世代のがんとくらしのサポート
  3. KOKORO.小林麻央のオフィシャルブログ by Ameba


深作眼科の手術 動画で見る深作眼科の手術 https://www.fukasaku.jp/movie/

Proliferative Diabetic Retinopathy Vitrectomy Tips and Tricks / RDP Trucos https://www.youtube.com/watch?v=0pQDUivh4ks

Live Surgical Demonstration: Proliferative Diabetic Retinopathy https://www.youtube.com/watch?v=pLCUZ3o3Tcg




  1. 新型コロナワクチンのデジタル予防接種記録を、マイクロソフトら大手12社が共同開発 (2021.01.21 07:00 realsound.jp)新型コロナワクチンの接種が各国で始まる中、海外渡航制限条件に多くの国が「予防接種記録」を追加している。現在存在する記録の中で一番メジャーなものが、WHOの発行する「国際予防接種証明書」、通称“イエローカード”と呼ばれるものだ。これは黄熱病コレラなどの伝染から、風疹などの子供の病気まで、幅広い予防接種歴を記録するものとして、現時点で一番普及している。… マイクロソフトをはじめとする12社の共同プロジェクトVCIVaccination Creditable Initiative)は「個人が暗号化された自身の予防接種記録を取得し、自由にそれぞれのヘルスアプリに連携していくシステムの構築」という大規模なビジョンを掲げている。




  1. 新型コロナ ワクチンパスポート EU導入へ議論開始 (会員限定有料記事 毎日新聞2021年1月21日 東京朝刊) 欧州連合(EU)が、新型コロナウイルスのワクチン接種証明を国境の自由な移動などの許可証とする、いわゆる「ワクチンパスポート」の導入について議論している。移動制限で観光業が低迷するギリシャなどが導入を求めるが、接種の強制や健康状態による差別につながりかねないとして慎重な意見も多い。
  2. 世界保健機関(WHO)は新型コロナウイルス感染拡大の状況に応じて、国外旅行者に対する免疫パスポート携帯義務の導入を検討する。WHOで緊急事態対応を統括するマイク・ライアン博士が15日の記者会見で発言した。(2021年01月16日 11:08 sputniknews.com)



ここでの論文数シェアとは、日本の国公私立大学の全論文数(分数カウント法)に占めるシェアを意味する。第1グループの上位4大学の論文数シェアは4.5%以上を占めている。(【論文数シェア(2009~2013年の論文数, 自然科学系)を用いた大学のグループ分類】 科学技術指標2019科学研究のベンチマーキング2019 2019年8月22日文部科学省科学技術・学術政策研究所)



「世界の論文投稿状況…主要国の動向(1)…各国の論文数と論文シェアの推移」が、「日本および世界の論文投稿状況の分析」(東京大学評価支援室インスティテューショナル・リサーチ担当船守美穂2012年3月6日 PDF)に示されていました。「論文数の推移(1981‐2010)」を見ると、中国の激増ぶりが凄いのですが、「論文数の世界シェアの推移(1981‐2010)」としてみると、アメリカの下落傾向が顕著に見えます。




(“Kyoto University”[Affiliation]) AND ((“2011/01/01″[Date – Publication] : “2011/12/31″[Date – Publication])) のような検索クエリで検索した結果、

    • 2010年1894報
  • 2011年2133報(前年比1.126倍の増加)
  • 2012年2194報(前年比1.028倍の増加)
  • 2013年2279報(前年比1.039倍の増加)
  • 2014年3090報(前年比1.036倍の増加)
  • 2015年3684報(前年比1.192倍の増加)
  • 2016年4024報(前年比1.042倍の増加)
  • 2017年4192報(前年比1.042倍の増加)
  • 2018年4300報(前年比1.026倍の増加)
  • 2019年4295報(前年比0.999倍の減少)
  • 2020年4880報(前年比1.136倍の増加、10年前比2.577倍の増加)















Global scientific output doubles every nine years (07 May 2014 | 16:46 GMT blog.nature.com)にも解説がありました。



Over the past 10 years, the number of PubMed-indexed papers published each year in PMC-OAS has grown, with the most recent years showing an exponential growth (Fig. 7).(Journal of Biomedical Semantics volume 6, Article number: 38 (2015))

上の論文数の推移をみると、確かに3倍くらいは軽く増えていました。別の文献を見ると、論文出版数の増加を言う際にWeb of Scienceなどを引用するのは間違いである。なぜなら毎年3%くらい収載する雑誌の数が増えているからと指摘しています。収載する雑誌が増えても、過去にさかのぼって論文を検索してくれるのであれば問題ないのではないでしょうか。

It’s clearly wrong to cite the growth of academic databases, such as Thomson Reuters Web of Science, which has increased its coverage by around 3% per year (barring occasions when the database incorporates a flood of new journals). That dramatically undercounts the true expansion: no database captures everything.


The increase in the number of searches was accompanied by a continuous increase in the number of records (i.e. the articles, abstracts and books included in the database) added in PubMed, as did those of other databases (Larsen & von Ins, 2010). A more dramatic increase in their numbers has occurred since 2004, when the number of records was approximately 15
million. By the first half of 2014 approximately 9.9 million more records have been added in Pubmed (a 66% increase from 2004), as evident from PubMed identification number (PMID) (http://www.nlm.nih.gov/bsd/licensee/baselinestats.html). This increase could be attributed to the increase in the number of researchers or an increase in their productivity. An analysis of several databases showed that despite the increase in literature, the productivity of scientists decreased, as shown by the number of papers per unique author (Larsen & von Ins, 2010). An analysis of PubMed records for the period 1978–2001 concluded that the growth of medical literature should be attributed to clinical research, while a shift away
from basic science was observed (Druss & Marcus, 2005). Simultaneously, an increase in new journal titles (the term used in PubMed for journals) was observed (3173 more titles in 2013 – new or due to title changes – compared to 2003)
(http://www.nlm.nih.gov/bsd/licensee/baselinestats.html), which might denote an increased demand for articles or a limited space in the available journals for the generated research. (An analysis of factors contributing to PubMed’s growth K.Z. Vardakas et al. / Journal of Informetrics 9 (2015) 592–617 有料)




上の話と若干食い違って見えるデータが、論文公表実態調査報告 2019 年度 (公開版)(大学図書館コンソーシアム連合 (JUSTICE) 2020 年 2 月 28 日)の中に にありました。これによれば、

国内研究者が Reprint Author となった公表論文数は 7 万件前後であり, 2012 年から 2017 年の 6 年間でほぼ横ばいである。

とのこと。データはWeb of Scienceで、ここではreprint Author(コレスポンディングオーサー)論文に限定しているので、条件が異なるのですが、それにしても大きな食い違いです。


PubMEDとWeb of Scienceとの食い違い

PubMEDとWeb of Scienceとでは収載している雑誌が多少異なるはずですが、それとは別に、検索条件でどんな文書を含めたかでも結果が変わってきます。文書の種類を何も限定せずにPubMED検索してしまうと、RetractionのNoticeや、ただの短いCommentなども拾ってしまうようです。PubMEDとWeb of Scienceとで条件を揃えて検索することがそもそもかなり難しいようですね。


近年爆発的に増加しているオープンアクセスジャーナルをどれくらい収載しているかの差かもしれないと思って、MDPI社の発行するジャーナルの数を調べてみました。MDPIの説明によれば、全部で304個のジャーナルを発行しているそうです。そのうちPUBMEDに収載されているのが76個。Web of Science収録が161個です。ですから、PUBMED検索結果のほうが多いことは、これでは説明がつきません。




  1. Comparison of PubMed, Scopus, Web of Science, and Google Scholar: Strengths and weaknesses March 2008The FASEB Journal 22(2):338-42 DOI: 10.1096/fj.07-9492LSF Full text at researchgate.com
  2. A behind-the-scenes guide for life scientists Michigan State University Q&A







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  60. アデノシンシグナルを介した妊娠高血圧腎症の病態機序の解明と臨床への応用を目指して
  61. 大動脈解離の病態機序解明と治療法開発を目的とした基礎・臨床研究
  62. プレシジョン医療実践のための病態機序解明とコンパニオン診断薬開発
  63. 口腔疾患特異的iPS細胞作製による病態機序の解明
  64. 過酸化水素シグナルに着目した、脂肪性肝疾患の新規病態機序・治療法の解明
  65. チタンアレルギーの病態機序および生体反応に関わる免疫学的研究
  66. タンパク質-RNA相互作用が及ぼす神経変性疾患の病態機序の解明
  67. CDKL5遺伝子変異によるてんかん性脳症のシナプス分子病態機序と治療法の解明
  68. T細胞の異常から捉えた神経変性疾患の病態機序解明と新規治療法開発
  69. 日本における抗PLA2R抗体関連膜性腎症の実態と病態機序の解明
  70. 肝線維化を誘導する特異的因子の発見・機能解析および病態機序の解明
  71. 変形性関節症における新しい病態機序-Transthyretin性アミロイド沈着-
  72. アデノシンシグナル経路を介した妊娠高血圧腎症の病態機序の解明と治療的可能性の検討
  73. ミトコンドリアCa2+制御機構とその破綻による心血管病態機序
  74. モデルショウジョウバエを用いたALS病態機序の解明と新規治療法への応用
  75. 自然リンパ球を標的とした好酸球性食道炎の病態機序の解明
  76. 分子イメージング手法を用いた2型糖尿病の病態機序の解明
  77. 脳アミロイドアンギオパチー関連炎症の病態機序の解明とバイオマーカーの確立
  78. 辺縁系脳炎型橋本脳症の臨床像と病態機序の解明
  79. タンパク質架橋化酵素を標的とした肝線維化の病態機序の解明および制御法の開発
  80. 難治性機能的脳疾患の病態機序としての視床-皮質律動異常の検証と治療への応用
  81. 半月体形成性腎炎における(プロ)レニン受容体を介した病態機序の解明と新規治療法
  82. 自己抗体を介する炎症性筋疾患の臨床像・筋病理の解析と病態機序の解明
  83. GFAP遺伝子異常症であるアレキサンダー病の臨床および病態機序に関する研究
  84. 慢性腎臓病の病態機序におけるメガリンの役割と尿中メガリン測定の臨床的意義
  85. SLC41輸送体群によるMg2+制御機構とその破綻に基づく病態機序
  86. COQ2変異に基づく多系統萎縮症の病態機序解明とサロゲートマーカーの開発
  87. 疾患動物モデルを用いた抗MuSK抗体陽性重症筋無力症の治療薬探索と病態機序の解明
  88. TDP-43・FUSによる翻訳・シナプス機能調節異常とALS・FTLD病態機序
  89. デングウイルス感染における重症化機序及びチクングンヤウイルスの病態機序解明
  90. C9FTD/ALSと孤発性ALSを繋ぐ病態機序の解明
  91. 皮質異形成の病態機序:体細胞変異仮説の検証
  92. 筋原性血管応答におけるイオン輸送分子の局在・活性制御とその異常が導く病態機序
  93. 犬と猫の糸球体腎症における病態機序の解明と新規診断・治療マーカーの探索
  94. 脳小血管病の解明と治療方法の確立:CARASILの病態機序からのアプローチ
  95. マイクロバイオーム解析とメタボローム解析による神経性食欲不振症の病態機序解明
  96. TDP43の自己調節機能に注目したALSの病態機序の解明
  97. 小脳失調型橋本脳症の臨床像と病態機序の解明
  98. プリオン病の病態機序におけるアストロサイトの役割に関する研究
  99. microRNAを標的とした関節リウマチの新規治療法開発と新病態機序解明への挑戦
  100. 神経発達障害原因遺伝子CDKL5の分子機能・病態機序の多元的アプローチによる解明
  101. 難治性ニューロパチーの軸索‐髄鞘間相互作用からみた病態機序の解明
  102. 新規HTRA1点変異ヘテロ接合体における脳小血管病の病態機序の解明
  103. クロウ-深瀬症候群の病態機序解明と再発予防に対する神経治療法開発
  104. 肥満関連液性因子ANGPTL2を介した、脂肪肝炎・肝臓癌の病態機序の解明
  105. 熱帯地域における手腕系振動障害に係る病態機序の解明
  106. スプライシング異常によるPOLDIP3の機能喪失に着目したALS病態機序の解明
  107. 脳内酸化ストレス反応を介した統合失調症の病態機序の解明
  108. 好酸球性副鼻腔炎の病態機序解明に対する真菌を用いたアプローチ
  109. 福山型先天性筋ジストロフィーの病態機序に基づいた治療法の確立
  110. TDP43の病態機序に基づいたALSの血中バイオマーカーの単離
  111. 重症くも膜下出血における神経原性肺水腫の病態機序と中枢性発症機構の解明
  112. 大動脈解離の分子病態機序の解明と新規治療法の開発
  113. 孤発性筋萎縮性側索硬化症の病態機序の解明
  114. TDP-43によるmicroRNA制御機構に着目したALS病態機序の解明
  115. 脳小血管障害の病態機序の解明:CARASILの病態機序からのアプローチ
  116. TDP43の生理機能に注目したALSの病態機序の解明
  117. 天然変性タンパク質の機能解析によるALSの病態機序の解明
  118. デスモグレイン3-GFP遺伝子組み換えマウスを用いた天疱瘡病態機序の検討
  119. 培養細胞モデルを用いたシヌクレイノパチー病態機序の解明
  120. パーキンソン病の幻視の発現病態機序の解明
  121. TDP-43の機能喪失に着目したALS病態機序の解明
  122. 周産期型低ホスファターゼ症の分子病態機序解析
  123. 妊娠高血圧症候群の病態機序へのスフィンゴシン1リン酸の関与の解明と治療への応用
  124. 神経筋疾患における筋組織内のアクアポリン発現性変化の病態機序に関する検討
  125. 上皮細胞カルシウム輸送体ファミリーの生理機能とその病態機序の解析
  126. 根尖性歯周疾患の病態機序-自然および獲得免疫応答と樹状細胞の成熟化-
  127. 変異グルコセレブロシダーゼによるパーキンソン病発症の病態機序の解明
  128. 筋萎縮性側索硬化症とTDP-43:その病理像の全貌と分子病態機序の解明
  129. 緑内障における外側膝状体の病態機序解明とその治療法の確立
  130. 血管内皮細胞成長因子の異常とニトロ化ストレス誘発糖尿病性血管障害の病態機序の解明
  131. 顔面肩甲上腕型筋ジストロフィーにおけるエピジェネティック変化と病態機序の解明
  132. 遺伝性脊髄小脳変性症における病態機序の解明と新規生化学的指標の同定
  133. モデルマウスを用いたタウオパチーの病態機序解明の総合的基盤研究
  134. カテコラミン産生調節細胞モデルを用いたシヌクレイノパチー病態機序の解析
  135. アンジオポエチン様因子ファミリー分子の、脂肪肝・脂肪性肝炎病態機序への関与の解明
  136. Na,Ca膜輸送分子複合体の機能制御とその病態機序の解析
  137. ゲノム解析を基盤とした神経疾患の病因・病態機序の解明
  138. 肥満および糖尿病モデルマウスを用いた血栓傾向の病態機序の解明と治療法の基礎的検討
  139. 神経調節性失神の病態機序解明と新しいトレーニング治療法の確立
  140. ブドウ球菌プロテアーゼ病理作用解析を基盤とした感染症病態機序の研究
  141. 遺伝性脳白質変性症の遺伝子解析および病態機序の解明
  142. 低ホスファターゼ症の分子病態機序の解明
  143. パールカンの神経筋接合部における機能解明―パールカン欠損病の病態機序解明をめざして
  144. 多発性筋炎の病態機序の解明(chemokineの側面から)
  145. 根尖性歯周疾患の病態機序の解明-樹状細胞の動態と免疫機能分子発現の解析-
  146. アプラタキシン欠損症の臨床遺伝学的検討および病態機序の解明
  147. カニクイザルにみられる遺伝性および加齢性黄斑変性の病態機序の解明
  148. 眼内新生血管における性差とその病態機序及び治療におけるエストロゲンの役割
  149. 心筋リモデリング特異因子の同定とその病態機序の解明
  150. 非アルツハイマー型変性痴呆の病態機序に関する研究-細胞骨格蛋白異常の観点から-
  151. Tilt Training:神経調節性失神の新しい治療法の開発と病態機序解明
  152. 筋強直性ジストロフィーの病態機序に関する研究
  153. ミトコンドリア血管症の病態機序の解明と遺伝子導入による機能修復
  154. 家族性痙性対麻痺の病態機序の解明
  155. 難治てんかんの分子病態機序の解明
  156. 脊髄小脳変性症の分子病態機序ならびに臨床病態の解明
  157. 遺伝子発現を基盤とする病態機序の解明法の開発
  158. 眼内炎症・眼内新生血管における性差とその病態機序・治療におけるエストロゲンの役割
  159. 筋萎縮性側索硬化症の分子病態機序に関する研究
  160. 筋萎縮性側索硬化症の分子病態機序の解明
  161. 赤血球膜蛋白P4.2の正常と病態における遺伝子発現制御と病態機序の研究
  162. 食道胃静脈瘤破裂の成因に関する静脈瘤血液ガス分析による病態機序の検討
  163. 心不全病態機序における低圧系調節システムの役割に関する実験的ならびに臨床的研究
  164. 術後一過性心筋梗塞様心電図の病態機序
  165. 脳血管攣縮の病態機序, その nucleotide cyclases 代謝
  166. 脳血管攣縮の病態機序


砂糖を取り過ぎると糖尿病になりやすいの?という疑問を感じたので、論文をあれこれ調べていたら、PLOS ONEのこんな論文を見つけました。

The relationship of sugar to population-level diabetes prevalence: an econometric analysis of repeated cross-sectional data. Basu S1, Yoffe P, Hills N, Lustig RH PLOS ONE  February 27, 2013 https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0057873


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