哺乳類胚の発生　卵割期　コンパクション compactionが起こる分子機構

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参考

  1. Mechanical strengthening of cell-cell adhesion during mouse embryo compaction Ludmilla de Plater Julie Firmin Jean-Léon Maître Open AccessPublished:March 25, 2024DOI:https://doi.org/10.1016/j.bpj.2024.03.028　Compaction requires the cell-cell adhesion molecule Cdh1, also known as E-cadherin and initially called uvomorulin after it was discovered in compacting mouse embryos.
  2. Cell-cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β-catenin　FEBS Lett. 2022 Jul; 596(13): 1647–1660. Published　FEBS Lett. 2022 Jul; 596(13): 1647–1660. Published online 2022
  3. Cell-cell adhesions in embryonic stem cells regulate the stability and transcriptional activity of β-catenin　Apr 6. doi: 10.1002/1873-3468.14341 PMCID: PMC10156795 NIHMSID: NIHMS1793009 PMID: 35344589
  4. Published: 06 August 2020 Transcriptomic analysis reveals differential gene expression, alternative splicing, and novel exons during mouse trophoblast stem cell differentiation Rahim Ullah, Ambreen Naz, Hafiza Sara Akram, Zakir Ullah, Muhammad Tariq, Aziz Mithani & Amir Faisal Stem Cell Research & Therapy volume 11, Article number: 342 (2020)　https://stemcellres.biomedcentral.com/articles/10.1186/s13287-020-01848-8
  5. Volume 21, Issue 13, 26 December 2017, Pages 3957-3969 Journal home page for Cell Reports Resource Protein Expression Landscape of Mouse Embryos during Pre-implantation Development　https://www.sciencedirect.com/science/article/pii/S2211124717317953
  6. How Adhesion Forms the Early Mammalian Embryo　2015White わかりやすい実験データの図およびまとめの細胞シグナルの図
  7. Making the first decision: lessons from the mouse Agnieszka Jedrusikcorresponding author 1 , 2 Reprod Med Biol. 2015 Oct; 14(4): 135–150. Published online 2015 Apr 16. doi: 10.1007/s12522-015-0206-8 PMCID: PMC5715835 PMID: 29259411 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5715835/
  8. RNA-Seq Transcriptome Profiling of Equine Inner Cell Mass and Trophectoderm1 Khursheed Iqbal, James L. Chitwood, Geraldine A. Meyers-Brown, Janet F. Roser, Pablo J. Ross Author Notes Biology of Reproduction, Volume 90, Issue 3, 1 March 2014, 61, 1-9, https://doi.org/10.1095/biolreprod.113.113928 Published: 01 March 2014
  9. Published: 13 August 2013 Changes in sub-cellular localisation of trophoblast and inner cell mass specific transcription factors during bovine preimplantation development Zofia E Madeja, Jaroslaw Sosnowski, Kamila Hryniewicz, Ewelina Warzych, Piotr Pawlak, Natalia Rozwadowska, Berenika Plusa & Dorota Lechniak BMC Developmental Biology volume 13, Article number: 32 (2013)https://bmcdevbiol.biomedcentral.com/articles/10.1186/1471-213X-13-32
  10. 細胞の極性化から眺めたマウス着床前の形作りの仕組み　2012.02.28　基礎生物学研究所　https://www.nibb.ac.jp/pressroom/news/2012/02/28.html　　　Prickle2タンパク質は、2細胞期から核で発現が開始し、8細胞期までは核内に局在。それ以降、胚盤胞期までは主に細胞質での粒子状の発現。　Prickle2遺伝子破壊マウスの表現型は、２５細胞期以降に胚盤胞が形成されない、また、栄養外胚葉への分化マーカーの発現が劇的に減少。頂底軸に沿ったいくつかのマーカー分子の発現が異常。Prickle2遺伝子は8細胞期に起こる細胞の極性確立に重要。その後の細胞の運命決定、胚盤胞の形成にも関与。　1.jpg
  11. ORAL PRESENTATION | OTHER: ART| VOLUME 94, ISSUE 4, SUPPLEMENT , S21, SEPTEMBER 2010 PDF [42 KB] Save Share Reprints Request Differential gene expression profiles between human embryo on day-3 and trophoblast cells on day-5: specific molecular signature S. Assou D. Haouzi F. Pellestor H. Dechaud J. De Vos S. Hamamah DOI:https://doi.org/10.1016/j.fertnstert.2010.07.082　https://www.fertstert.org/article/S0015-0282(10)01187-8/fulltext
  12. Development . 2004 Dec;131(23):5817-24. doi: 10.1242/dev.01458. Epub 2004 Nov 3. Stabilization of beta-catenin in the mouse zygote leads to premature epithelial-mesenchymal transition in the epiblast　https://pubmed.ncbi.nlm.nih.gov/15525667/
  13. 15 SEPTEMBER 2004 Maternal β-catenin and E-cadherin in mouse development Wilhelmine N. de Vries, Alexei V. Evsikov, Bryce E. Haac, Karen S. Fancher, Andrea E. Holbrook, Rolf Kemler, Davor Solter, Barbara B. Knowles Author and article information Development (2004) 131 (18): 4435–4445.　https://journals.biologists.com/dev/article/131/18/4435/42290/Maternal-catenin-and-E-cadherin-in-mouse
  14. Regulation of cell adhesion during embryonic compaction of mammalian embryos: roles for PKC and beta-catenin C M Pauken 1, D G Capco Mol Reprod Dev . 1999 Oct;54(2):135-44. doi: 10.1002/(SICI)1098-2795(199910)54:2<135::AID-MRD5>3.0.CO;2-A.　https://pubmed.ncbi.nlm.nih.gov/10471473/

 

参考

カテニンの細胞接着における役割

  • Cadherins：single transmembrane domain glycoproteins that mediate calcium-dependent cell–cell adhesion via homophilic interactions
  • The intracellular domain of E-cadherin associates with a protein family collectively termed catenins.
  • β-catenin and γ-catenin (plakoglobin) interact directly with E-cadherin’s COOH-terminal domain in a mutually exclusive way, and both proteins associate with α-catenin, which links the cadherin complexes to the actin cytoskeleton and mediates stable cell adhesion.
  • p120ctn is another catenin family member, which binds to the cytoplasmic juxtamembrane portion of E-cadherin and influences E-cadherin clustering and adhesive strength.

カテニンのwntシグナリングにおける役割

  • wnt不在のとき：細胞質β-cateninは axin/conductinやadenomatous polyposis coli tumor suppressor proteinと複合体をつくり、 glycogen synthase kinase 3βによってN末がリン酸化を受けておりプロテオソームによる分解を受ける。
  • wntが受容体frizzledに結合すると、一連のシグナル経路によってglycogen synthase kinase 3βによるβ-cateninリン酸化が抑制され、β-cateninは安定化。
  • 安定化したβ-cateninは、high mobility group (HMG) box転写因子であるlymphoid enhancer binding factor (LEF)-1/T cell factor (TCF) ファミリーと結合する.
  • 核内β-catenin–LEF/TCF複合体はhistone acetylase p300/CBPなどのコアクチベーターと結合して、TATA-binding protein TBPの発現を促進したり, groucho-related gene 5 などとの結合により遺伝子発現を抑制したりする。

（とある論文のイントロ部分のまとめ）

  1. OCT4 Coordinates with WNT Signaling to Pre-pattern Chromatin at the SOX17 Locus during Human ES Cell Differentiation into Definitive Endoderm　Stem Cell Reports. 2015 Oct 13; 5(4): 490–498. Published online 2015 Sep 24. doi: 10.1016/j.stemcr.2015.08.014 PMCID: PMC4624996 PMID: 26411902
  2. The E-Cadherin and N-Cadherin Switch in Epithelial-to-Mesenchymal Transition: Signaling, Therapeutic Implications, and Challenges　Cells. 2019 Oct; 8(10): 1118. Published online 2019 Sep 20. doi: 10.3390/cells8101118 PMCID: PMC6830116 PMID: 31547193 https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6830116/　An external file that holds a picture, illustration, etc. Object name is cells-08-01118-g002.jpg
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