以前はbasic FGFという言葉をよく見かけたのに最近見かけないなあと思っていました。FGFとbasic FGFとは、何が違うのでしょうか。ChatGPT 4oに訊いてみました。

“Basic FGF” (bFGF), or FGF2, is one specific member of the fibroblast growth factor (FGF) family. The term “FGF” is a broader designation that encompasses a family of related proteins involved in various cellular processes, including cell growth, differentiation, wound healing, and angiogenesis.

Here’s a breakdown of the distinction:

1. FGF (Fibroblast Growth Factors):
   • This is a family of growth factors with 22 known members in humans, each with unique roles and specificities. They are designated by numbers (e.g., FGF1, FGF2, FGF3, etc.).
   • FGFs are essential for developmental processes, tissue repair, and other physiological functions.
2. Basic FGF (bFGF or FGF2):
   • FGF2 is a particular type of FGF known for its role in promoting angiogenesis (formation of new blood vessels), wound healing, and supporting the growth of fibroblasts.
   • It is termed “basic” because of its relatively high isoelectric point, distinguishing it from “acidic FGF” (aFGF or FGF1), which has a lower isoelectric point.

In summary, “basic FGF” or FGF2 refers specifically to one member of the FGF family with particular biological functions and properties, while “FGF” refers to the entire family of fibroblast growth factors.