未分化な性腺における遺伝子発現

Gonadal primordia is observed in humans in week 5 of gestation, being under the control of WT1, NR5A1, NR0B1, CBX1/2, LHX9, EMX2, GATA4, and SIX1/4 [15].

Studies in mice have shown that, at this moment, genes that are associated with Sertoli (testicular) (SOX9, FGF9, PGD2) or granulosa (ovarian) (WNT4, RSPO1, CTNNB1, FST) differentiation are expressed at similar levels in both the XY and XX fetus [16,17,18].

https://www.mdpi.com/2075-4418/11/8/1379