強心配糖体（きょうしん はいとうたい) Cardiac glycosidex

スポンサーリンク

強心配糖体（きょうしん はいとうたい）(Cardiac glycoside)とは、不整脈などの治療に用いられるステロイド配糖体のことだそうです。

  1. 強心配糖体（ウィキペディア）

強心配糖体の構造的な特徴、標的となる分子への作用は以下の動画がわかりやすい。

Cardiac glycosides in easy way egpat チャンネル登録者数 13.4万人

Digoxin (ジゴキシン)の作用

Digoxin Nursing Pharmacology NCLEX (Cardiac Glycosides) RegisteredNurseRN チャンネル登録者数 229万人

 

強心剤とは

  1. 強心剤（コトバンク）
  2. ジギタリス製剤（コトバンク）

 

強心配糖体の抗腫瘍作用に関する論文

    1. Localized Microsphere/Hydrogel for Tumor Immunotherapy of Cardiac Glycoside with Minimal Toxicity Gao L et al. 2022 ACS Appl Mater Interfaces. 2022 Dec 20. doi: 10.1021/acsami.2c18693. Online ahead of print.
    2. Pharmaco-Toxicological Assessment of the Combined Cytotoxic Effects of Digoxin and Betulinic Acid in Melanoma Cells Rednic R et al. 2022 Life (Basel). 2022 Nov 11;12(11):1855. doi: 10.3390/life12111855.
    3. Periplocin exerts antitumor activity by regulating Nrf2-mediated signaling pathway in gemcitabine-resistant pancreatic cancer cells Bae ES et al. 2023 Biomed Pharmacother. 2023 Jan;157:114039. doi: 10.1016/j.biopha.2022.114039. Epub 2022 Nov 21.
    4. Digoxin as an emerging therapy in noncardiac diseases Dashti F et al. 2022 Trends Pharmacol Sci. 2022 Nov 5:S0165-6147(22)00228-0. doi: 10.1016/j.tips.2022.10.002. Online ahead of print.
    5. Evaluation of the Sensitivity of Breast Cancer Cell Lines to Cardiac Glycosides Unveils ATP1B3 as a Possible Biomarker for the Personalized Treatment of ERα Expressing Breast Cancers Acconcia F et al. 2022 Int J Mol Sci. 2022 Sep 21;23(19):11102. doi: 10.3390/ijms231911102.
    6. Glycoside oleandrin downregulates toll-like receptor pathway genes and associated miRNAs in human melanoma cells Eroğlu Güneş C et al. 2022 Gene. 2022 Nov 15;843:146805. doi: 10.1016/j.gene.2022.146805. Epub 2022 Aug 11.
    7. Proscillaridin A Sensitizes Human Colon Cancer Cells to TRAIL-Induced Cell Death Semba M et al. 2022 Int J Mol Sci. 2022 Jun 23;23(13):6973. doi: 10.3390/ijms23136973.
    8. Antitumor effects of oleandrin in different types of cancers: Systematic review Francischini CRD et al. 2022 Toxicon. 2022 Sep;216:15-27. doi: 10.1016/j.toxicon.2022.06.010. Epub 2022 Jun 27.
    9. Convallatoxin suppresses osteosarcoma cell proliferation, migration, invasion, and enhances osteogenic differentiation by downregulating parathyroid hormone receptor 1 (PTHR1) expression and inactivating Wnt/β-catenin pathway Liu X et al. 2022 Bioengineered. 2022 May;13(5):13280-13292. doi: 10.1080/21655979.2022.2080363.
    10. Cytotoxic cardiac glycosides from the root of Streblus asper Osman Mohammed RM et al. 2022 Phytochemistry. 2022 Aug;200:113239. doi: 10.1016/j.phytochem.2022.113239. Epub 2022 May 25.
    11. The Botanical Drug PBI-05204, a Supercritical CO(2) Extract of Nerium Oleander, Is Synergistic With Radiotherapy in Models of Human Glioblastoma Colapietro A et al. 2022 Front Pharmacol. 2022 Mar 23;13:852941. doi: 10.3389/fphar.2022.852941. eCollection 2022.
    12. Inhibition of the Na(+)/K(+)-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation Shandell MA et al. 2022 J Biol Chem. 2022 Mar;298(3):101707. doi: 10.1016/j.jbc.2022.101707. Epub 2022 Feb 9.
    13. Periplocymarin Induced Colorectal Cancer Cells Apoptosis Via Impairing PI3K/AKT Pathway Cheng Y et al. 2021 Front Oncol. 2021 Nov 25;11:753598. doi: 10.3389/fonc.2021.753598. eCollection 2021.
    14. The Cardiac Glycoside Deslanoside Exerts Anticancer Activity in Prostate Cancer Cells by Modulating Multiple Signaling Pathways Liu M et al. 2021 Cancers (Basel). 2021 Nov 19;13(22):5809. doi: 10.3390/cancers13225809.
    15. Suppression of ER-stress induction of GRP78 as an anti-neoplastic mechanism of the cardiac glycoside Lanatoside C in pancreatic cancer: Lanatoside C suppresses GRP78 stress induction Ha DP et al. 2021 Neoplasia. 2021 Dec;23(12):1213-1226. doi: 10.1016/j.neo.2021.10.004. Epub 2021 Nov 9.
    16. Lanatoside C inhibits human cervical cancer cell proliferation and induces cell apoptosis by a reduction of the JAK2/STAT6/SOCS2 signaling pathway Duan Y et al. 2021 Oncol Lett. 2021 Oct;22(4):740. doi: 10.3892/ol.2021.13001. Epub 2021 Aug 17.
    17. Repurposing proscillaridin A in combination with decitabine against embryonal rhabdomyosarcoma RD cells Huot M et al. 2021 Cancer Chemother Pharmacol. 2021 Nov;88(5):845-856. doi: 10.1007/s00280-021-04339-6. Epub 2021 Jul 31.
    18. Cardiac Glycoside Ouabain Exerts Anticancer Activity via Downregulation of STAT3 Du J et al. 2021 Front Oncol. 2021 Jun 30;11:684316. doi: 10.3389/fonc.2021.684316. eCollection 2021.
    19. Structural Insights into the Interactions of Digoxin and Na(+)/K(+)-ATPase and Other Targets for the Inhibition of Cancer Cell Proliferation Ren Y et al. 2021 Molecules. 2021 Jun 16;26(12):3672. doi: 10.3390/molecules26123672.
    20. Quo vadis Cardiac Glycoside Research? Bejček J et al. 2021 Toxins (Basel). 2021 May 11;13(5):344. doi: 10.3390/toxins13050344.
    21. Malayoside, a cardenolide glycoside extracted from Antiaris toxicaria Lesch, induces apoptosis in human non-small lung cancer cells via MAPK-Nur77 signaling pathway Hu QY et al. 2021 Biochem Pharmacol. 2021 Aug;190:114622. doi: 10.1016/j.bcp.2021.114622. Epub 2021 May 24.
    22. Oleandrin, a cardiac glycoside, induces immunogenic cell death via the PERK/elF2α/ATF4/CHOP pathway in breast cancer Li X et al. 2021 Cell Death Dis. 2021 Mar 24;12(4):314. doi: 10.1038/s41419-021-03605-y.
    23. Ouabain Exhibited Strong Anticancer Effects in Melanoma Cells via Induction of Apoptosis, G2/M Phase Arrest, and Migration Inhibition Wang L et al. 2021 Onco Targets Ther. 2021 Feb 25;14:1261-1273. doi: 10.2147/OTT.S283548. eCollection 2021.
    24. Antiviral Effects of Oleandrin Newman RA et al. 2020 J Exp Pharmacol. 2020 Nov 16;12:503-515. doi: 10.2147/JEP.S273120. eCollection 2020.
    25. Proscillaridin A inhibits hepatocellular carcinoma progression through inducing mitochondrial damage and autophagy Luo M et al. 2021 Acta Biochim Biophys Sin (Shanghai). 2021 Jan 12;53(1):19-28. doi: 10.1093/abbs/gmaa139.
    26. Cardiac glycosides from the roots of Streblus asper Lour. and their apoptosis-inducing activities in A549 cells Zhang BD et al. 2021 Phytochemistry. 2021 Jan;181:112544. doi: 10.1016/j.phytochem.2020.112544. Epub 2020 Oct 30.
    27. Antitumor Activity of the Cardiac Glycoside αlDiginoside by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells Weng JR et al. 2020 Int J Mol Sci. 2020 Oct 26;21(21):7947. doi: 10.3390/ijms21217947.
    28. Screening of medicinal herbs for cytotoxic activity to leukemia cells Thi Kim Ly B et al. 2020 J BUON. 2020 Jul-Aug;25(4):1989-1996.
    29. Inhibition of JNK-Mediated Autophagy Promotes Proscillaridin A- Induced Apoptosis via ROS Generation, Intracellular Ca(+2) Oscillation and Inhibiting STAT3 Signaling in Breast Cancer Cells Saleem MZ et al. 2020 Front Pharmacol. 2020 Sep 4;11:01055. doi: 10.3389/fphar.2020.01055. eCollection 2020.
    30. Cardiac glycosides inhibit cancer through Na/K-ATPase-dependent cell death induction Geng X et al. 2020 Biochem Pharmacol. 2020 Dec;182:114226. doi: 10.1016/j.bcp.2020.114226. Epub 2020 Sep 22.
    31. Targeting the Otub1/c-Maf axis for the treatment of multiple myeloma Xu Y et al. 2021 Blood. 2021 Mar 18;137(11):1478-1490. doi: 10.1182/blood.2020005199.
    32. Targeting UHRF1-dependent DNA repair selectively sensitizes KRAS mutant lung cancer to chemotherapy Tian D et al. 2020 Cancer Lett. 2020 Nov 28;493:80-90. doi: 10.1016/j.canlet.2020.08.008. Epub 2020 Aug 16.
    33. Prospects and Therapeutic Applications of Cardiac Glycosides in Cancer Remediation Ayogu JI et al. 2020 ACS Comb Sci. 2020 Nov 9;22(11):543-553. doi: 10.1021/acscombsci.0c00082. Epub 2020 Aug 24.
    34. Triple-Negative Breast Cancer Cells Exhibit Differential Sensitivity to Cardenolides from Calotropis gigantea Pederson PJ et al. 2020 J Nat Prod. 2020 Jul 24;83(7):2269-2280. doi: 10.1021/acs.jnatprod.0c00423. Epub 2020 Jul 10.
    35. Bufalin inhibits hepatitis B virus-associated hepatocellular carcinoma development through androgen receptor dephosphorylation and cell cycle-related kinase degradation Yu Z et al. 2020 Cell Oncol (Dordr). 2020 Dec;43(6):1129-1145. doi: 10.1007/s13402-020-00546-0. Epub 2020 Jul 4.
    36. Implications for glycosylated compounds and their anti-cancer effects Pourakbari R et al. 2020 Int J Biol Macromol. 2020 Nov 15;163:1323-1332. doi: 10.1016/j.ijbiomac.2020.06.281. Epub 2020 Jul 3.
    37. A Phase II, Single-Arm, Open-Label, Bayesian Adaptive Efficacy and Safety Study of PBI-05204 in Patients with Stage IV Metastatic Pancreatic Adenocarcinoma Roth MT et al. 2020 Oncologist. 2020 Oct;25(10):e1446-e1450. doi: 10.1634/theoncologist.2020-0440. Epub 2020 Jul 2.
    38. Digoxin lowers the incidence of prostate cancer: A nationwide population-based study Lin TP et al. 2020 J Chin Med Assoc. 2020 Apr;83(4):377-381. doi: 10.1097/JCMA.0000000000000288.
    39. Na(+)/K(+)-ATPase-Targeted Cytotoxicity of (+)-Digoxin and Several Semisynthetic Derivatives Ren Y et al. 2020 J Nat Prod. 2020 Mar 27;83(3):638-648. doi: 10.1021/acs.jnatprod.9b01060. Epub 2020 Feb 25.
    40. Downregulation of BIS sensitizes A549 cells for digoxin-mediated inhibition of invasion and migration by the STAT3-dependent pathway Yun HH et al. 2020 Biochem Biophys Res Commun. 2020 Apr 9;524(3):643-648. doi: 10.1016/j.bbrc.2020.01.154. Epub 2020 Feb 4.
    41. Strophanthidin Attenuates MAPK, PI3K/AKT/mTOR, and Wnt/β-Catenin Signaling Pathways in Human Cancers Reddy D et al. 2020 Front Oncol. 2020 Jan 17;9:1469. doi: 10.3389/fonc.2019.01469. eCollection 2019.
    42. Proscillaridin A slows the prostate cancer progression through triggering the activation of endoplasmic reticulum stress Wang F et al. 2020 Cell Cycle. 2020 Mar;19(5):541-550. doi: 10.1080/15384101.2020.1716484. Epub 2020 Feb 2.
    43. Oleandrin induces apoptosis via activating endoplasmic reticulum stress in breast cancer cells Li XX et al. 2020 Biomed Pharmacother. 2020 Apr;124:109852. doi: 10.1016/j.biopha.2020.109852. Epub 2020 Jan 20.
    44. Cytotoxic and non-cytotoxic cardiac glycosides isolated from the combined flowers, leaves, and twigs of Streblus asper Ren Y et al. 2020 Bioorg Med Chem. 2020 Feb 15;28(4):115301. doi: 10.1016/j.bmc.2019.115301. Epub 2020 Jan 7.
    45. Cardiac glycosides are broad-spectrum senolytics Guerrero A et al. 2019 Nat Metab. 2019 Nov;1(11):1074-1088. doi: 10.1038/s42255-019-0122-z. Epub 2019 Oct 21.
    46. Cardiac Glycoside Compound Isolated from Helleborus thibetanus Franch Displays Potent Toxicity against HeLa Cervical Carcinoma Cells through ROS-Independent Autophagy Man S et al. 2019 Chem Res Toxicol. 2019 Dec 16;32(12):2479-2487. doi: 10.1021/acs.chemrestox.9b00318. Epub 2019 Nov 12.
    47. A novel source of the cardiac glycoside digoxin from the endophytic fungus Epicoccum nigrum: isolation, characterization, production enhancement by gamma irradiation mutagenesis and anticancer activity evaluation El-Sayed ER et al. 2020 J Appl Microbiol. 2020 Mar;128(3):747-762. doi: 10.1111/jam.14510. Epub 2019 Nov 22.
    48. Proscillaridin A induces apoptosis and inhibits the metastasis of osteosarcoma in vitro and in vivo Fang S et al. 2020 Biochem Biophys Res Commun. 2020 Jan 22;521(4):880-886. doi: 10.1016/j.bbrc.2019.11.012. Epub 2019 Nov 7.
    49. Ouabain signaling in oral squamous cell carcinoma cells Saito S et al. 2019 J Oral Sci. 2019 Nov 27;61(4):498-503. doi: 10.2334/josnusd.18-0411. Epub 2019 Sep 20.
    50. The In Vitro Anti-Cancer Activities of 17βH-Neriifolin Isolated from Cerbera odollam and its Binding Activity on Na+, K+-ATPase Yunos NM et al. 2020 Curr Pharm Biotechnol. 2020;21(1):37-44. doi: 10.2174/1389201020666190917154850.
    51. [Cancer cell-specific functional relation between Na(+),K(+)-ATPase and volume-regulated anion channel] Fujii T et al. 2019 Nihon Yakurigaku Zasshi. 2019;154(3):103-107. doi: 10.1254/fpj.154.103.
    52. Circadian sensitivity to the cardiac glycoside oleandrin is associated with diurnal intestinal P-glycoprotein expression Zhou C et al. 2019 Biochem Pharmacol. 2019 Nov;169:113622. doi: 10.1016/j.bcp.2019.08.024. Epub 2019 Aug 28.
    53. Bufalin, a Traditional Chinese Medicine Compound, Prevents Tumor Formation in Two Murine Models of Colorectal Cancer Sun X et al. 2019 Cancer Prev Res (Phila). 2019 Oct;12(10):653-666. doi: 10.1158/1940-6207.CAPR-19-0134. Epub 2019 Aug 20.
    54. Cardiac glycoside sensitized hepatocellular carcinoma cells to TRAIL via ROS generation, p38MAPK, mitochondrial transition, and autophagy mediation Rasheduzzaman M et al. 2019 Mol Carcinog. 2019 Nov;58(11):2040-2051. doi: 10.1002/mc.23096. Epub 2019 Aug 8.
    55. A new cardenolide glycoside from the roots of Streptocaulon juventas (lour.) merr. (Asclepiadaceae) Bui XH et al. 2021 Nat Prod Res. 2021 Apr;35(7):1192-1198. doi: 10.1080/14786419.2019.1641806. Epub 2019 Aug 1.
    56. Hydro-ethanol seed extract of Theobroma cacao exhibits antioxidant activities and potential anticancer property Ebuehi OAT et al. 2019 J Food Biochem. 2019 Apr;43(4):e12767. doi: 10.1111/jfbc.12767. Epub 2019 Feb 5.
    57. Anti-epileptic effect of 16-O-acetyldigitoxigenin via suppressing mTOR signaling pathway Tu W et al. 2019 Cell Mol Biol (Noisy-le-grand). 2019 Jun 30;65(5):59-63.
    58. Oxidative stress as candidate therapeutic target to overcome microenvironmental protection of CLL Yosifov DY et al. 2020 Leukemia. 2020 Jan;34(1):115-127. doi: 10.1038/s41375-019-0513-x. Epub 2019 Jul 12.
    59. Targeting β2 subunit of Na(+)/K(+)-ATPase induces glioblastoma cell apoptosis through elevation of intracellular Ca(2) Li S et al. 2019 Am J Cancer Res. 2019 Jun 1;9(6):1293-1308. eCollection 2019.
    60. Ouabain-regulated phosphoproteome reveals molecular mechanisms for Na(+), K(+)-ATPase control of cell adhesion, proliferation, and survival Panizza E et al. 2019 FASEB J. 2019 Sep;33(9):10193-10206. doi: 10.1096/fj.201900445R. Epub 2019 Jul 10.
    61. Heart failure drug proscillaridin A targets MYC overexpressing leukemia through global loss of lysine acetylation Da Costa EM et al. 2019 J Exp Clin Cancer Res. 2019 Jun 13;38(1):251. doi: 10.1186/s13046-019-1242-8.
    62. Cardiac glycoside cerberin exerts anticancer activity through PI3K/AKT/mTOR signal transduction inhibition Hossan MS et al. 2019 Cancer Lett. 2019 Jul 1;453:57-73. doi: 10.1016/j.canlet.2019.03.034. Epub 2019 Mar 28.
    63. Lanatoside C protects mice against bleomycin-induced pulmonary fibrosis through suppression of fibroblast proliferation and differentiation Nie Y et al. 2019 Clin Exp Pharmacol Physiol. 2019 Jun;46(6):575-586. doi: 10.1111/1440-1681.13081. Epub 2019 Apr 7.
    64. Divaricoside Exerts Antitumor Effects, in Part, by Modulating Mcl-1 in Human Oral Squamous Cell Carcinoma Cells Weng JR et al. 2019 Comput Struct Biotechnol J. 2019 Jan 26;17:151-159. doi: 10.1016/j.csbj.2019.01.004. eCollection 2019.
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    66. The connection between the cardiac glycoside-induced senescent cell morphology and Rho/Rho kinase pathway Şimay YD et al. 2018 Cytoskeleton (Hoboken). 2018 Nov;75(11):461-471. doi: 10.1002/cm.21502. Epub 2018 Dec 7.
    67. Systems biology-based drug repositioning identifies digoxin as a potential therapy for groups 3 and 4 medulloblastoma Huang L et al. 2018 Sci Transl Med. 2018 Oct 24;10(464):eaat0150. doi: 10.1126/scitranslmed.aat0150.
    68. Proscillaridin A exerts anti-tumor effects through GSK3β activation and alteration of microtubule dynamics in glioblastoma Berges R et al. 2018 Cell Death Dis. 2018 Sep 24;9(10):984. doi: 10.1038/s41419-018-1018-7.
    69. A cardiac glycoside HTF-1 isolated from Helleborus thibetanus Franch displays potent in vitro anti-cancer activity via caspase-9, MAPK and PI3K-Akt-mTOR pathways Ma L et al. 2018 Eur J Med Chem. 2018 Oct 5;158:743-752. doi: 10.1016/j.ejmech.2018.09.019. Epub 2018 Sep 13.
    70. Sodium chloride (NaCl) potentiates digoxin-induced anti-tumor activity in small cell lung cancer Deng K et al. 2019 Cancer Biol Ther. 2019;20(1):52-64. doi: 10.1080/15384047.2018.1504723. Epub 2018 Sep 5.
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    72. Tissue distribution study of periplocin and its two metabolites in rats by a validated LC-MS/MS method Liu H et al. 2018 Biomed Chromatogr. 2018 Oct;32(10):e4302. doi: 10.1002/bmc.4302. Epub 2018 Jun 26.
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    75. Cardiac glycoside bufalin blocks cancer cell growth by inhibition of Aurora A and Aurora B activation via PI3K-Akt pathway Xie CM et al. 2018 Oncotarget. 2018 Feb 9;9(17):13783-13795. doi: 10.18632/oncotarget.24475. eCollection 2018 Mar 2.
    76. Cardiac Glycoside Glucoevatromonoside Induces Cancer Type-Specific Cell Death Schneider NFZ et al. 2018 Front Pharmacol. 2018 Mar 1;9:70. doi: 10.3389/fphar.2018.00070. eCollection 2018.
    77. Lanatoside C inhibits cell proliferation and induces apoptosis through attenuating Wnt/β-catenin/c-Myc signaling pathway in human gastric cancer cell Hu Y et al. 2018 Biochem Pharmacol. 2018 Apr;150:280-292. doi: 10.1016/j.bcp.2018.02.023. Epub 2018 Feb 21.
    78. Ouabain suppresses the growth and migration abilities of glioma U‑87MG cells through inhibiting the Akt/mTOR signaling pathway and downregulating the expression of HIF‑1α Yang XS et al. 2018 Mol Med Rep. 2018 Apr;17(4):5595-5600. doi: 10.3892/mmr.2018.8587. Epub 2018 Feb 12.
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    87. The cardiac glycoside convallatoxin inhibits the growth of colorectal cancer cells in a p53-independent manner Anderson SE et al. 2017 Mol Genet Metab Rep. 2017 Aug 7;13:42-45. doi: 10.1016/j.ymgmr.2017.07.011. eCollection 2017 Dec.
    88. Anti-tumorigenic effects of a novel digitoxin derivative on both estrogen receptor-positive and triple-negative breast cancer cells Kulkarni YM et al. 2017 Tumour Biol. 2017 Jun;39(6):1010428317705331. doi: 10.1177/1010428317705331.
    89. The cardiac glycoside oleandrin induces apoptosis in human colon cancer cells via the mitochondrial pathway Pan L et al. 2017 Cancer Chemother Pharmacol. 2017 Jul;80(1):91-100. doi: 10.1007/s00280-017-3337-2. Epub 2017 Jun 8.
    90. Digoxin Attenuates Murine Experimental Colitis by Downregulating Th17-related Cytokines Tani S et al. 2017 Inflamm Bowel Dis. 2017 May;23(5):728-738. doi: 10.1097/MIB.0000000000001096.
    91. Cardiac glycosides suppress the maintenance of stemness and malignancy via inhibiting HIF-1α in human glioma stem cells Lee DH et al. 2017 Oncotarget. 2017 Jun 20;8(25):40233-40245. doi: 10.18632/oncotarget.16714.
    92. Lanatoside C, a cardiac glycoside, acts through protein kinase Cδ to cause apoptosis of human hepatocellular carcinoma cells Chao MW et al. 2017 Sci Rep. 2017 Apr 7;7:46134. doi: 10.1038/srep46134.
    93. (+)-Strebloside-Induced Cytotoxicity in Ovarian Cancer Cells Is Mediated through Cardiac Glycoside Signaling Networks Chen WL et al. 2017 J Nat Prod. 2017 Mar 24;80(3):659-669. doi: 10.1021/acs.jnatprod.6b01150. Epub 2017 Feb 24.
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    95. A new semisynthetic cardenolide analog 3β-[2-(1-amantadine)- 1-on-ethylamine]-digitoxigenin (AMANTADIG) affects G2/M cell cycle arrest and miRNA expression profiles and enhances proapoptotic survivin-2B expression in renal cell carcinoma cell lines Nolte E et al. 2017 Oncotarget. 2017 Feb 14;8(7):11676-11691. doi: 10.18632/oncotarget.14644.
    96. Cardiac Glycoside Constituents of Streblus asper with Potential Antineoplastic Activity Ren Y et al. 2017 J Nat Prod. 2017 Mar 24;80(3):648-658. doi: 10.1021/acs.jnatprod.6b00924. Epub 2016 Dec 16.
    97. Delivery of acetylthevetin B, an antitumor cardiac glycoside, using polymeric micelles for enhanced therapeutic efficacy against lung cancer cells Zhu JJ et al. 2017 Acta Pharmacol Sin. 2017 Feb;38(2):290-300. doi: 10.1038/aps.2016.113. Epub 2016 Dec 5.
    98. Bcl-2 protein family expression pattern determines synergistic pro-apoptotic effects of BH3 mimetics with hemisynthetic cardiac glycoside UNBS1450 in acute myeloid leukemia Cerella C et al. 2017 Leukemia. 2017 Mar;31(3):755-759. doi: 10.1038/leu.2016.341. Epub 2016 Nov 22.
    99. Cardiac glycosides and breast cancer risk: A systematic review and meta-analysis of observational studies Karasneh RA et al. 2017 Int J Cancer. 2017 Mar 1;140(5):1035-1041. doi: 10.1002/ijc.30520. Epub 2016 Nov 27.
    100. Octreotide-periplocymarin conjugate prodrug for improving targetability and anti-tumor efficiency: synthesis, in vitro and in vivo evaluation Zhang HY et al. 2016 Oncotarget. 2016 Dec 27;7(52):86326-86338. doi: 10.18632/oncotarget.13389.
    101. Cytotoxic cardiac glycosides from the fruit (pods) of Adenium obesum (Forssk.) Roem. & Schult Ahmed SK et al. 2017 Nat Prod Res. 2017 May;31(10):1205-1208. doi: 10.1080/14786419.2016.1226826. Epub 2016 Sep 1.
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    103. Digoxin is a selective modifier increasing platinum drug anticancer activity Bogush TA et al. 2016 Dokl Biochem Biophys. 2016 May;468(1):220-3. doi: 10.1134/S1607672916030170. Epub 2016 Jul 15.
    104. Dual activities of the anti-cancer drug candidate PBI-05204 provide neuroprotection in brain slice models for neurodegenerative diseases and stroke Van Kanegan MJ et al. 2016 Sci Rep. 2016 May 12;6:25626. doi: 10.1038/srep25626.
    105. Peruvoside, a Cardiac Glycoside, Induces Primitive Myeloid Leukemia Cell Death Feng Q et al. 2016 Molecules. 2016 Apr 22;21(4):534. doi: 10.3390/molecules21040534.
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