Angina Bullosa Haemorrhagica (ABH) is considered a rare condition. However, overview of English language literature of the case reports in the last 05 years revealed that the condition is not as uncommon as it was considered previously (Table-1). (Angina bullous haemorrhagica: Case report and review of literature Case report J Pak Med Assoc Vol. 68, No. 10, October 2018)
ABH treatment may include the use of anti-inflammatory and antibiotic agents, as well as antisepsis with mouthwash containing 0.25% or 0.12% chlorhexidine digluconate, to help relief painful
symptoms and avoid secondary infections2,12,13,18,19. Because secondary infection of areas of ulceration are not uncommon, it is of paramount importance that the patient be provided with appropriate information and adequately followed. Patients presenting with lesions affecting the soft palate should be immediately prescribed antibiotic prophylactic therapy; in our study, all patients with lesions at the soft palate developed secondary infection. In other
regions, patient follow-up will reveal whether the use of antibiotics is needed or not. There is a recommendation in the literature
that oral antiseptics such as chlorhexidine digluconate be prescribed to all patients, as these agents seem to have an important role in the prevention of infections after blister rupture. Our findings apparently confirm the benefit of that recommendation: no antiseptic agent was prescribed before the clinical diagnosis of infection, and all four cases with lesions affecting the soft palate developed secondary infections after rupture.
Giant Angina Bullosa Haemorrhagica Indian Dermatol Online J . 2020 Nov 8;11(6):1036-1037. doi: 10.4103/idoj.IDOJ_431_19. eCollection Nov-Dec 2020.
Angina bullosa haemorrhagica: a systematic review and proposal for diagnostic criteria International Journal of Oral and Maxillofacial Surgery Volume 48, Issue 1, January 2019, Pages 28-39
An Oral Hemorrhagic Blister That Heals Spontaneously Mohammad Ali El-DaroutiFaiza Mohamed Al-Ali 1. 2. Challenging Cases in Dermatology Volume 2 pp 37-41 Chapter First Online: 29 August 2019 Springer Link
Angina bullosa hemorrhagica of the soft palate: a clinical study of 16 cases Journal of Oral Science/50 巻 (2008) 1 号 J-STAGE
Angina bullosa hemorrhagica of the soft palate: report of 11 cases and literature review J Oral Maxillofac Surg . 2006 Sep;64(9):1433-6. doi: 10.1016/j.joms.2005.11.058.
The Cancer Genome Atlas (TCGA) provides researchers with unprecedented amounts of molecular data along with clinical and histopathological information (http:// cancergenome.nih.gov/). This data set has not only led to increases in our understanding of cancer (Ciriello et al., 2013; Hoadley et al., 2014), but its scale has also allowed for previously impossible projects such as a comprehensive cataloguing of the human transcriptome (Han et al., 2014; Iyer et al., 2015).
Identification of key genes and pathways by bioinformatics analysis with TCGA RNA sequencing data in hepatocellular carcinoma Authors: Qiandong Zhu Yunpeng Sun Qingqing Zhou Qikuan He Haixin Qian View Affiliations Published online on: September 27, 2018 https://doi.org/10.3892/mco.2018.1728
It’s rare, affecting about 5.2 people per 100,000 in the U.S. population, according to the National ALS Registry. https://www.webmd.com/brain/who-gets-als
On average, people with ALS (PALS) die due to respiratory failure 2 to 4 years after the onset of symptoms. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8380909/
About 10% of those with the condition will live 10 years, and 5% will live for 20 or more years. https://www.verywellhealth.com/als-lou-gehrigs-disease-life-expectancy-2223973
Unfortunately, the prognosis for ALS is poor. ALS is a progressive condition that is terminal within five years for 80% of the people impacted by it. https://www.verywellhealth.com/als-lou-gehrigs-disease-life-expectancy-2223973
Generally, ALS is categorized in one of two ways: Upper motor neuron disease affects nerves in the brain, while lower motor neuron disease affects nerves coming from the spinal cord or brainstem. In both cases, motor neurons are damaged and eventually die. ALS is fatal. The average life expectancy after diagnosis is two to five years, but some patients may live for years or even decades. (The famous physicist Stephen Hawking, for example, lived for more than 50 years after he was diagnosed.) There is no known cure to stop or reverse ALS.
Each person with ALS experiences a different proportion of upper and lower motor neurons that die. This results in symptoms that vary from person to person. https://www.hss.edu/condition-list_amyotrophic-lateral-sclerosis.asp