Hormesis was first defined by toxicologists who observed beneficial effects of very low doses of poisonous substances (‘poisons’).
‘Hormesis’ as defined by Southam and Ehrlich (1943) applies to
short- or long-lasting beneficial effects activated in cells after a
‘moderate’ stress (or harmful stimulus).
Hormesis is the idea that short, intermittent bursts of certain stressors can start a cascade of cellular processes that slow aging, improve overall health and make you more resilient, both physically and mentally. https://carolinatotalwellness.com/blog/index.php/2023/03/03/hormesis-the-beneficial-type-of-stress/
the concept of hormesis is about 130 years old, starting with the findings of Hugo Schulz [26,27] concerning the effects of nearly a dozen disinfectants on yeast metabolism. Schulz’s research was significant as it established the biphasic dose response within the framework of a modest overcompensation response to an initial disruption in homeostasis.
Schulz erroneously associated his biphasic dose response with the practice of homeopathy, asserting that he had discovered its explanatory principle [34]. This action of Schulz curtailed his career.
The term hormesis was first used in the peer-reviewed literature by Southam and Ehrlich [1] in 1943 to describe the effects of extracts of the red cedar tree on the growth of numerous fungal species that had the capacity to rot wood.
Biological stress response terminology: Integrating the concepts of adaptive response and preconditioning stress within a hormetic dose–response framework https://escholarship.org/uc/item/4q35r8nb
pre- and postconditioning are specific types of hormesis. https://www.sciencedirect.com/science/article/abs/pii/S1043661815301912?via%3Dihub
Preconditioning is a specific type of hormesis(Calabrese 2016a,b). https://apsjournals.apsnet.org/doi/pdf/10.1094/PDIS-10-17-1638-RE
Cell Survival Programs and Ischemia/Reperfusion: Hormesis, Preconditioning, and Cardioprotection (Colloquium Integrated Systems Physiology: From Molecule to Function to Disease) https://www.amazon.com/Cell-Survival-Programs-Ischemia-Reperfusion/dp/1615045848
Hormesis in Cholestatic Liver Disease; Preconditioning with Low Bile Acid Concentrations Protects against Bile Acid-Induced Toxicity https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0149782
Preconditioning is hormesis part I https://www.sciencedirect.com/science/article/abs/pii/S1043661815301912
Preconditioning is hormesis part II https://www.sciencedirect.com/science/article/abs/pii/S1043661815301924?via%3Dihub
