ヒト受精卵～卵割期～二層性胚盤胞の遺伝子発現プロファイル

1細胞

  1. Cell Stem Cell. 2022 Feb 3; 29(2): 209–216.e4. doi: 10.1016/j.stem.2021.11.012 PMCID: PMC8826644 PMID: 34936886 Human embryonic genome activation initiates at the one-cell stage　https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8826644/

2細胞

ヒトは内部細胞塊が２つに分かれて一卵性双生児が誕生するくらいですから、「調節卵」の代表です。しかし、あらためて観察してみると2細胞のときからすでに「差」はあるようです。調節卵だからどの割球も差がなくて一様というわけではないのかもしれません。

The first two blastomeres contribute unequally to the human embryo　Cell論文　Volume 187, Issue 11p2838-2854.e17May 23, 2024

4細胞

Volume 165, Issue 1p61-74March 24, 2016Open access Download Full Issue Heterogeneity in Oct4 and Sox2 Targets Biases Cell Fate in 4-Cell Mouse Embryos　CELL　https://www.cell.com/cell/fulltext/S0092-8674(16)30061-7

8細胞

  1. Evaluate the developmental competence of human 8-cell embryos by single-cell RNA sequencing　Online Publication Date: 19 Apr 2023　https://raf.bioscientifica.com/view/journals/raf/4/2/RAF-22-0119.xml

桑実胚

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STEM CELLS STEM CELLS Concise Review Free Access Oct-4: Gatekeeper in the Beginnings of Mammalian Development Maurizio Pesce, Hans R. Schöler Ph.D. First published: 01 January 2009 https://doi.org/10.1634/stemcells.19-4-271https://stemcellsjournals.onlinelibrary.wiley.com/doi/10.1634/stemcells.19-4-271

TEとEpiblastへの分化

　Volume 95, Issue 3, 30 October 1998, Pages 379-391 Journal home page for Cell Article Formation of Pluripotent Stem Cells in the Mammalian Embryo Depends on the POU Transcription Factor Oct4　CELL　https://www.sciencedirect.com/science/article/pii/S0092867400817699

  1. Nature. 2017 Oct 5; 550(7674): 67–73. Published online 2017 Sep 20. doi: 10.1038/nature24033 PMCID: PMC5815497 EMSID: EMS73931 PMID: 28953884 Genome editing reveals a role for OCT4 in human embryogenesis

シングルセル解析

  1. A Comprehensive Human Embryogenesis Reference Tool using Single-Cell RNA-Sequencing Data　Posted February 02, 2024.　BioRxiv　https://www.biorxiv.org/content/10.1101/2021.05.07.442980v4.full
  2. Volume 18, Issue 8, 8 August 2023, Pages 1621-1628 Journal home page for Stem Cell Reports Report Transcriptomic differences between human 8-cell-like cells reprogrammed with different methods　Stem Cell Reports　https://www.sciencedirect.com/science/article/pii/S2213671123002382
  3. Single-cell RNA sequencing reveals abnormal fluctuations in human eight-cell embryos associated with blastocyst formation failure　Molecular Human Reproduction, Volume 28, Issue 1, January 2022, gaab069, https://doi.org/10.1093/molehr/gaab069
  4. Published: 13 July 2021 Single cell RNA-seq reveals genes vital to in vitro fertilized embryos and parthenotes in pigs　Scientific Reports　https://www.nature.com/articles/s41598-021-93904-3
  6. Single-Cell RNA-Seq Reveals Lineage and X Chromosome Dynamics in Human Preimplantation Embryos　CELL　Volume 165, Issue 4p1012-1026May 05, 2016　https://www.cell.com/fulltext/S0092-8674(16)30280-X