カエルの卵とFGF

• The presence of fibroblast growth factor in the frog egg: its role as a natural mesoderm inducer D Kimelman 1, J A Abraham, T Haaparanta, T M Palisi, M W Kirschner Science . 1988 Nov 18;242(4881):1053-6. doi: 10.1126/science.3194757. PMID: 3194757 DOI: 10.1126/science.3194757　the oocyte and early embryo contain a store of the FGF polypeptide at high enough concentrations to induce mesoderm. The presence of FGF in the oocyte, together with the apparent lack of a secretory signal sequence in the protein, suggest that the regulation of mesoderm induction may involve novel mechanisms that occur after the translation of FGF.