Tregとがんとの関係
制御性T細胞（Treg）は免疫を抑制する方向で働き、過剰な免疫応答を抑制しています。しかし、がんにおいては、がんと闘うべき免疫システムを抑制するという好ましくない状態を作り出してしまします。
Regulatory T cells (Tregs) were initially identified in both mice [1] and humans [2] as CD4+ T cells constitutively expressing the α receptor to IL-2 (CD25) and inhibiting the immune response of effector T cells, notably their production of interferon-γ. These cells are known to be a key contributor to the maintenance of immune tolerance, preventing the emergence of organ-specific auto-immune disease. However, in cancer-bearing animals or patients, Tregs expand, migrate to tumor sites and suppress antitumor immune response mediated by NK cells, CD4+ and CD8+ T cells, and myeloid cells, through different molecular mechanisms [3]. The discovery that the transcription factor forkhead box P3 (FOXP3) was a more specific marker for distinguishing Tregs from other populations of T lymphocytes [4] strengthened their identity. Thus, nuclear immunolabeling with anti-FOXP3 antibodies has been widely used to characterize Treg cells on tissue sections, notably in human tumors.（Prognostic role of FOXP3+ regulatory T cells infiltrating human carcinomas: the paradox of colorectal cancer Cancer Immunology, Immunotherapy volume 60, pages909–918 (2011)）
- CD4 and FOXP3 as predictive markers for the recurrence of T3/T4a stage II colorectal cancer: applying a novel discrete Bayes decision rule BMC Cancer volume 22, Article number: 1071 (2022) 18 October 2022
- The prognostic value of tumor-infiltrating lymphocytes in colorectal cancer differs by anatomical subsite: a systematic review and meta-analysis World Journal of Surgical Oncology volume 17, Article number: 85 (2019)
- FOXP3+ Tregs: heterogeneous phenotypes and conflicting impacts on survival outcomes in patients with colorectal cancer Immunologic Research volume 61, pages338–347 (2015) 大腸癌における制御性T細胞の役割に関する相反する報告のレビュー
- CD4+ T Cells Expressing Latency-Associated Peptide and Foxp3 Are an Activated Subgroup of Regulatory T Cells Enriched in Patients with Colorectal Cancer Published: September 30, 2014 https://doi.org/10.1371/journal.pone.0108554
- Expression of Foxp3 in Colorectal Cancer but Not in Treg Cells Correlates with Disease Progression in Patients with Colorectal Cancer Published: January 30, 2013 https://doi.org/10.1371/journal.pone.0053630
- Regulatory (FoxP3+) T-cell Tumor Infiltration Is a Favorable Prognostic Factor in Advanced Colon Cancer Patients Undergoing Chemo or Chemoimmunotherapy J Immunother. 2010 May; 33(4): 435–441. doi: 10.1097/CJI.0b013e3181d32f01 PMCID: PMC7322625 NIHMSID: NIHMS1597178 PMID: 20386463
- High density of FOXP3-positive T cells infiltrating colorectal cancers with microsatellite instability British Journal of Cancer volume 99, pages1867–1873 (2008) Published: 04 November 2008
制御性T細胞に関する論文
- Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases S Sakaguchi 1, N Sakaguchi, M Asano, M Itoh, M Toda J Immunol . 1995 Aug 1;155(3):1151-64.