左右軸の決定機構

左右軸形成の分子機構の解明に関する全てはこの論文から始まったといえるでしょう。この論文を見たとき自分は、左右を決めるだけのことなのに、こんなややこしいことが本当に起きているのだろうかとかなり懐疑的な気分になりました。それから２０年以上が経過して、このメカニズムは揺るぎないものとなり生物学の教科書に当然のように紹介されています。

Randomization of Left–Right Asymmetry due to Loss of Nodal Cilia Generating Leftward Flow of Extraembryonic Fluid in Mice Lacking KIF3B Motor Protein Shigenori Nonaka ∙ Yosuke Tanaka ∙ Yasushi Okada ∙ Sen Takeda ∙ Akihiro Harada ∙ Yoshimitsu Kanai ∙ Mizuho Kido ∙ Nobutaka Hirokawa*　Cell Volume 95, Issue 6p829-837December 11, 1998　https://www.cell.com/cell/fulltext/S0092-8674(00)81705-5

訂正 In this paper (Cell 95[6], 829–837), we described the direction of the nodal cilia rotation as counterclockwise (Figure 6B). However, our recent analyses with higher spatiotemporal resolution revealed that the actual direction is clockwise when seen from the ventral side (above the nodal pit cells). In our previous observation with lower temporal resolution (10 frames per second), the direction of the rapid rotation (∼10 rounds per second) of the nodal cilia was misinterpreted due to the artifact caused by the strobe effect. ‥　For further details, refer to our recent paper Y. Okada et al. (Molecular Cell, 1999, in press). https://www.cell.com/cell/fulltext/S0092-8674(00)80067-7

レビュー論文

  1. Nodal Flow and the Generation of Left-Right Asymmetry Cell Volume 125, Issue 1, 7 April 2006, Pages 33-45 https://www.sciencedirect.com/science/article/pii/S009286740600300X このレビュー論文では線毛が動く様子や蛍光ビーズが左側に流れていく様子などを示したわかりやすい動画も掲載されています。

左右軸形成に関する論文

  1. Molecular anatomy of emerging Xenopus left–right organizer at successive developmental stages Natalia Petri, Alexandra Vetrova, Nikoloz Tsikolia, Stanislav Kremnyov Developmental Dynamics First published: 27 June 2024 https://doi.org/10.1002/dvdy.722
  2. R-Spondin 2 governs Xenopus left-right body axis formation by establishing an FGF signaling gradient　Nature Communications  Published: 02 February 2024
  3. A dual function of FGF signaling in Xenopus left-right axis formation Isabelle Schneider, Jennifer Kreis, Axel Schweickert, Martin Blum, Philipp Vick Development 01 January 2019  https://journals.biologists.com/dev/article/doi/10.1242/dev.173575/264844/am/A-dual-function-of-FGF-signaling-in-Xenopus-left
  4. The Left-Right Coordinator: The Role of Vg1 in Organizing Left-Right Axis Formation Cell 3 April 1998; Volume 93, Issue 1, Pages 37-46
  5. Developmental Biology Volume 189, Issue 1, 1 September 1997, Pages 68-78 Developmental Biology Regular Article Organizer Induction Determines Left–Right Asymmetry inXenopus