発生における上皮-間充織相互作用
生物学では『間充織」（かんじゅうしき）、医学では「間」（かんよう）と呼び方が異なりますが、同一のものを指しています。このブログでは特に使い分けをせずに、どちらも使うことにします。
- Jean Paul Thiery, Hervé Acloque, Ruby Y.J. Huang, M. Angela Nieto, Epithelial-Mesenchymal Transitions in Development and Disease, Cell, Volume 139, Issue 5, 2009, Pages 871-890, ISSN 0092-8674,
四肢の形成と上皮-間充織相互作用
The apical ectodermal ridge (AER) maintains the mesenchyme in a proliferating state (preventing it from form cartilage) that enables the linear growth of the limb; maintains the expression of those molecules that generate the anterior-posterior axis; interacts with the proteins specifying the anterior-posterior and dorsal-ventral axis. AER formation requires
bone morphogenetic protein (BMP) signaling and can be prevented in transgenic mice by expressing a dominant negative BMP receptor under the control of an epidermis-specific promoter. The signal for limb bud formation comes from mesodermal cells, which secrete FGF-10, capable of initiating interactions between the ectoderm and mesoderm (Xu et al., 1998, Yonei-Tamura et al.,1999). FGF-10 induces the overlying ectoderm to form the AER.
Moreover, FGF-10 induces the AER to synthesize and secrete FGF-8, which stimulates mitosis in the mesenchymal cells. The FGF-10 knockout mouse forms no limb buds.Int. J. Dev. Biol. 58: 303 – 306 (2014) https://doi.org/10.1387/ijdb.140143dr Vol 58, Issue 5 Epithelial-mesenchymal interactions: a fundamental Developmental Biology mechanism Essay | Published: 30 September 2014 Domenico Ribatti* and Marcello Santoiemma
Limbs emerge from the body flank as a consequence of localized epithelial–mesenchymal interactions that result in rapid proliferation of mesenchymal cells leading to the formation of limb buds. https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/lateral-plate-mesoderm
参考資料
- 学術俯瞰講義 平成18年度冬学期講義「生命の科学」 「発生生物学からみた生命科学」 浅島 誠 （東京大学大学院総合文化研究科 教授）
- The lateral plate mesoderm Karin D. Prummel,1,2,* Susan Nieuwenhuize,1,2,* and Christian Mosimann1,2,‡ Development. 2020 Jun 15; 147(12): dev175059. Published online 2020 Jun 19. doi: 10.1242/dev.175059 PMCID: PMC7328003
