カエルの発生学で分子シグナルが詳細に調べられてきましたが、それらの分子がマウス胚でも同様の働きをもつのかどうかの情報の整理が大変です。
Goosecoid
- Goosecoid Regulates the Neural Inducing Strength of the Mouse Node Developmental Biology Volume 216, Issue 1, 1 December 1999, Pages 276-281
- Gastrulation in the mouse: the role of the homeobox gene goosecoid M Blum, SJ Gaunt, KWY Cho, H Steinbeisser, B Blumberg, D Bittner, EM De Robertis Cell, 1992 本文有料
- TGIF1 and TGIF2 regulate Nodal signaling and are required for gastrulation. January 2010Development 137(2):249-59 DOI:10.1242/dev.040782 https://www.researchgate.net/figure/Regulation-of-goosecoid-expression-by-Tgifs-AEmbryos-of-the-indicated-ages-and_fig6_40812258 (C)Expression of goosecoid in 8.0 dpc embryos of the indicated genotypes was analyzed by in situ hybridization. (D)Sections through the embryos in C.
Cがgoosecoidの発現。nodeに局在していることがわかります。
Chordin
下の図でaがchordinのin situ hybridazation (mRNAの局在)です。bcはnoggin遺伝子の発現。chordinは原始線条の前側で発現しはじめて原始結節に局在したと本文で説明されていますが、図には向きなどの記載がなくわかりにくいです。Chordin遺伝子をのノックアウトしても表現型は意外なくらいマイルド(図efg)なようです。
The organizer factors Chordin and Noggin are required for mouse forebrain development Nature volume 403, pages658–661 (2000) 10 February 2000 https://www.nature.com/articles/35001072
wntシグナリング分子
https://www.semanticscholar.org/paper/Wnt-signalling-in-mouse-gastrulation-and-anterior-Arkell-Fossat/1ebceb654e1ea878ac1bd663735be63e1a14a0fb
Canonical Wnt Signaling and Its Antagonist Regulate Anterior-Posterior Axis Polarization by Guiding Cell Migration in Mouse Visceral Endoderm Developmental Cell Volume 9, Issue 5, November 2005, Pages 639-650 https://www.sciencedirect.com/science/article/pii/S1534580705003734