複雑な細胞内情報伝達経路を英語で簡潔に説明するのは容易ではありませんが、論文のイントロなどを書くときには必要となります。IP3/Ca経路を説明した英語の文章を見てみます。
論文 Calcium Signaling 1995 レビュー論文
- Two receptor classes, the G protein-coupled receptor class of seven transmembrane-spanning receptors (GCRs) and the receptor tyrosine kinases (RTKs), release InsP3 via the pathways shown in Figure la.
- GCRs activate phospholipase Cβ (PLCβ), while RTKs stimulate phospholipase Cγ (PLCγ ) to convert phosphatidylinositol (4,5)-bisphosphate (PtdlnsP2) into InsP3 and diacylglycerol.
- InsP3 acts as an intracellular second messenger by binding to the specialized tetrameric InsP3 receptor that spans the endoplasmic reticular membrane
- and triggering release of Ca 2+ from the ER.
次の文例は、シグナル経路が３つに分岐することを簡潔に説明しています。また、説明しつつまだわかっていないことにも言及しています。
- Receptor tyrosine kinases (RTKs) and their cognate ligands are often used in multiple tissues within an organism to mediate distinct functions.
- Activated vertebrate RTKs typically stimulate multiple downstream effectors, including RAS, phosphatidylinositol-3-kinase (PI3K) and phospholipase Cγ(PLCγ).
- Activation of the RAS/MAPK pathway is necessary and sufficient for mitogenesis in certain systems
- while PI3K function is involved in transformation and membrane ruffling as well as other phenotypes.
- Activation of PLCγ promotes release of intracellular calcium through production of the second messenger inositol trisphosphate (IP3), but the in vivo role of calcium in eliciting mitogenesis is unclear and appears to vary among cell types and RTKs.
その他の参考論文