シトクロムP450とは

シトクロムはほとんど全ての生物種がもっている酵素で、酸素分子を用いて有機物を酸化することができます。還元型で一酸化炭素が結合したときに450nmの吸収の極大を持つことからこう名付けられました。ヘムを持つたんぱく質で、多様性があり多数のファミリーに分類されまています。

1. タンパク質の高次構造形成過程における プロリン残基の役割：シトクロムP450 の場合　生物物理 41（4）, 181-185（2001）

生物にとっての異物、毒物や、薬などの代謝に関係しています。

ChatGPTによる説明

https://chat.openai.com/chat　で質問してみました。What is cytochrome P450?　以下、その答えです。

Cytochrome P450 (CYP450) is a family of enzymes that play a crucial role in the metabolism of many drugs, toxins, and endogenous compounds in the human body. These enzymes are found in many tissues, including the liver, lungs, kidneys, and intestines, and are involved in the oxidation of organic substances.

CYP450 enzymes are responsible for the breakdown of a wide range of substances, including pharmaceutical drugs, hormones, and environmental toxins. They are important in drug metabolism because they can change the chemical structure of drugs, often making them more water-soluble and easier for the body to eliminate.

There are many different types of CYP450 enzymes, each with a unique structure and substrate specificity. These enzymes are identified by a specific number, such as CYP1A2 or CYP3A4, and are regulated by various factors, including genetics, diet, and environmental factors. Because of the important role that CYP450 enzymes play in drug metabolism, they are often the target of drug-drug interactions, which can affect the effectiveness and safety of medications.

集合知って凄いですね。