ショウジョウバエの体節形成と体節形成遺伝子、３つの表現型分類

ペアルール遺伝子群

　https://en.wikipedia.org/wiki/Pair-rule_gene

odd-paired遺伝子

odd-paired (opa)はペアルール遺伝子の一つ。

1. Cell-specific occupancy dynamics between the pioneer-like factor Opa/ZIC and Ocelliles/OTX regulate early head development in embryos　Posted December 16, 2022.　https://www.biorxiv.org/content/10.1101/2022.12.15.519123v1.full
2. Odd-Paired: The Drosophila Zic Gene　Adv Exp Med Biol . 2018:1046:41-58. doi: 10.1007/978-981-10-7311-3_3. https://pubmed.ncbi.nlm.nih.gov/29442316/　Zinc finger in the cerebellum (Zic) proteins are a family of transcription factors with multiple roles during development, particularly in neural tissues. The founding member of the Zic family is the Drosophila odd-paired (opa) gene. The Opa protein has a DNA binding domain containing five Cys2His2-type zinc fingers and has been shown to act as a sequence-specific DNA binding protein. Opa has significant homology to mammalian Zic1, Zic2, and Zic3 within the zinc finger domain and in two other conserved regions outside that domain. opa was initially identified as a pair-rule gene, part of the hierarchy of genes that establish the segmental body plan of the early Drosophila embryo. However, its wide expression pattern during embryogenesis indicates it plays additional roles. Embryos deficient in opa die before hatching with aberrant segmentation but also with defects in larval midgut formation. Post-embryonically, opa plays important roles in adult head development and circadian rhythm.
3. Odd-paired is a pioneer-like factor that coordinates with Zelda to control gene expression in embryos　Jul 23, 2020 https://doi.org/10.7554/eLife.59610
4. Odd-paired controls frequency doubling in Drosophila segmentation by altering the pair-rule gene regulatory network Erik Clark Is a corresponding authorMichael Akam University of Cambridge, United Kingdom Aug 15, 2016 https://doi.org/10.7554/eLife.18215 https://elifesciences.org/articles/18215
5. Odd paired transcriptional activation of decapentaplegic in the Drosophila eye/antennal disc is cell autonomous but indirect　Developmental Biology Volume 343, Issues 1–2 , 1–15 July 2010, Pages 167-177　https://www.sciencedirect.com/science/article/pii/S0012160610002332　The gene odd paired (opa), a Drosophila homolog of the Zinc finger protein of the cerebellum (Zic) family of mammalian transcription factors, plays roles in embryonic segmentation and development of the adult head.
6. Emerging roles for zic genes in early development Christa S. Merzdorf First published: 01 March 2007 https://anatomypubs.onlinelibrary.wiley.com/doi/10.1002/dvdy.21098
7. The Zic family member, odd-paired, regulates the Drosophila BMP, decapentaplegic, during adult head development 01 April 2007  DEVELOPMENT https://journals.biologists.com/dev/article/134/7/1301/53041/The-Zic-family-member-odd-paired-regulates-the   …  However, the postembryonic role of opa is completely unknown. … We find that opa is expressed in the eye/antennal disc, primarily in the peripodial epithelium of this structure. Loss of opa function during eye/antennal disc development results in defects in ventral head structures identical to those observed with loss of dpp.