知能とポリジェニックスコアの論文

Doust, C., Fontanillas, P., Eising, E. et al. Discovery of 42 genome-wide significant loci associated with dyslexia. Nat Genet 54, 1621–1629 (2022). https://doi.org/10.1038/s41588-022-01192-y

2022. Okbay, A., Wu, Y., Wang, N. et al. Polygenic prediction of educational attainment within and between families from genome-wide association analyses in 3 million individuals. Nat Genet 54, 437–449 (2022). https://doi.org/10.1038/s41588-022-01016-z

2022. Abdellaoui, A., Dolan, C.V., Verweij, K.J.H. et al. Gene–environment correlations across geographic regions affect genome-wide association studies. Nat Genet 54, 1345–1354 (2022). https://doi.org/10.1038/s41588-022-01158-0 educational attainment polygenic scores capture gene–environment correlations

Jansen PR, Nagel M, Watanabe K, Wei Y, Savage JE, de Leeuw CA, van den Heuvel MP, van der Sluis S, Posthuma D. Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence.  Nat Commun. 2020 Nov 5;11(1):5606. doi: 10.1038/s41467-020-19378-5.
PMID: 33154357

Evidence for Recent Polygenic Selection on Educational Attainment and Intelligence Inferred from Gwas Hits: A Replication of Previous Findings Using Recent Data by Davide Piffer Department of Biology, Tuebingen University, 72074 Tuebingen, Germany Psych 2019, 1(1), 55-75; https://doi.org/10.3390/psych1010005 Published: 28 March 2019

2018. Savage, J.E., Jansen, P.R., Stringer, S. et al. Genome-wide association meta-analysis in 269,867 individuals identifies new genetic and functional links to intelligence. Nat Genet 50, 912–919 (2018). https://doi.org/10.1038/s41588-018-0152-6Intelligence is highly heritable” (Abstract 冒頭)https://ctg.cncr.nl/software/summary_statistics SavageJansen_IntMeta_sumstats.zip  (461.36 MB)

Suzanne Sniekers et al. Genome-wide association meta-analysis of 78,308 individuals identifies new loci and genes influencing human intelligence Nature Genetics, 2017,Jul;49(7):1107-1112. https://ctg.cncr.nl/software/summary_statistics

2015. Polderman, T., Benyamin, B., de Leeuw, C. et al. Meta-analysis of the heritability of human traits based on fifty years of twin studies. Nat Genet 47, 702–709 (2015). https://doi.org/10.1038/ng.3285 ”Despite a century of research on complex traits in humans, the relative importance and specific nature of the influences of genes and environment on human traits remain controversial.” (Abstract 冒頭)

1988. Genetic influence on general mental ability increases between infancy and middle childhood D. W. Fulker, J. C. DeFries and R. Plomin Nature  Vol. 336 Issue 6201 Pages 767-9