四肢の形成機構

AER

www.frontiersin.org

Activation of the WNT-BMP-FGF Regulatory Network Induces the Onset of Cell Death in Anterior Mesodermal Cells to Establish the ANZ　Front. Cell Dev. Biol., 08 November 2021 Sec. Cell Death and Survival Volume 9 – 2021 | https://doi.org/10.3389/fcell.2021.703836

 

 

Front. Genet., 07 January 2019 Sec. Stem Cell Research Volume 9 – 2018 | https://doi.org/10.3389/fgene.2018.00705 This article is part of the Research Topic FGF10 in Development, Homeostasis, Disease and Repair After Injury View all 19 articles Fibroblast Growth Factor 10 and Vertebrate Limb Development　https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00705/fullwww.frontiersin.org

 

2017年　https://anatomypubs.onlinelibrary.wiley.com/doi/pdf/10.1002/dvdy.24480

ニワトリの四肢形成

Developmental Biology Volume 273, Issue 2, 15 September 2004, Pages 361-372 Developmental Biology The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth　https://www.sciencedirect.com/science/article/pii/S0012160604004282　

 

マウスの四肢形成

Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function Save Related Papers Chat with paper Marie Kmita, Basile Tarchini, Jozsef Zàkàny, Malcolm Logan, Clifford J. Tabin & Denis Duboule Nature volume 435, pages1113–1116 (2005)　Published: 23 June 2005　https://www.nature.com/articles/nature03648　figure 2

15 November 2002 growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb Ying Liu, Chunqiao Liu, Yoshihiko Yamada, Chen-Ming Fan Author and article information Development (2002) 129 (22): 5289–5300.

Fig. 1. Gas1 transcripts are detected in developing limbs. Expression ofGas1 was examined by ISH. (A-C) Dorsal view of the forelimbs at E9.25, E9.5 and E10.5. Anterior (a) is at top and posterior (p) at bottom;flb, forelimb bud. Gas1 is expressed in the lateral plate mesoderm and asymmetrically in the limbs with higher levels anteriorly. (D-G)Whole-mount ISH of E11.5-E14.5 forelimbs shows expression in the autopod(dorsal view, anterior at top). White arrowheads indicate the interdigital regions; open arrowheads, perichondorgenic regions; asterisks, joints or prospective joints. (H-K) 35S-ISH of E10.5-E15.5 forelimbs(horizontal sections, anterior at top). (H) Superimposed images from adjacent sections of E10.5 Gas1 expression (red) in anterior two-thirds of the mesenchyme but not in AER (visualized by Fgf8 expression (green) in the adjacent section). At E12.5 (I), Gas1 transcripts (pink granules)are prominent in the prechondrogenic region (black arrowheads) and the interdigits (white arrowheads). At E13.5 (J), Gas1 is expressed in the interdigits (much weaker than at E12.5) and prospective joints(asterisks). At E15.5 (K), Gas1 is localized to perichondrium lining the joint cavities (asterisks).