四肢の発生、形成機構、手指の発生・形成

  1. 四肢(上肢と下肢)の発生・形成、頭部、顔の発生・形成

四肢の発生講義動画

下の動画は説明がうまくて非常にわかりやすい解説だと思いました。四肢の発生は複雑ですが、形態形成の概念、シグナル分子、遺伝子変異による形態の変化など、テンポ良く解説していってくれます。

Tetrapod limb development | Molecules and signaling pathways regulating Limb development| Embryology Animated biology With arpan チャンネル登録者数 29.3万人 (17:28)

The Embryology Behind Congenital Hand Differences Little Arms: a resource for parents and physicians チャンネル登録者数 2390人

  1. macrodactyly 名 《病理》巨指症

Congenital deformities of the Upper Limb Orthopaedic Principles チャンネル登録者数 4.82万人

Congenital hand I: Embryology, classification, and principles

AER

www.frontiersin.org

Activation of the WNT-BMP-FGF Regulatory Network Induces the Onset of Cell Death in Anterior Mesodermal Cells to Establish the ANZ Front. Cell Dev. Biol., 08 November 2021 Sec. Cell Death and Survival Volume 9 – 2021 | https://doi.org/10.3389/fcell.2021.703836

 

 

Front. Genet., 07 January 2019 Sec. Stem Cell Research Volume 9 – 2018 | https://doi.org/10.3389/fgene.2018.00705 This article is part of the Research Topic FGF10 in Development, Homeostasis, Disease and Repair After Injury View all 19 articles Fibroblast Growth Factor 10 and Vertebrate Limb Development https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2018.00705/fullwww.frontiersin.org

 

2017年 https://anatomypubs.onlinelibrary.wiley.com/doi/pdf/10.1002/dvdy.24480

ニワトリの四肢形成

Developmental Biology Volume 273, Issue 2, 15 September 2004, Pages 361-372 Developmental Biology The roles of Fgf4 and Fgf8 in limb bud initiation and outgrowth https://www.sciencedirect.com/science/article/pii/S0012160604004282 

 

マウスの四肢形成

Early developmental arrest of mammalian limbs lacking HoxA/HoxD gene function Save Related Papers Chat with paper Marie Kmita, Basile Tarchini, Jozsef Zàkàny, Malcolm Logan, Clifford J. Tabin & Denis Duboule Nature volume 435, pages1113–1116 (2005) Published: 23 June 2005 https://www.nature.com/articles/nature03648 figure 2

15 November 2002 growth arrest specific gene 1 acts as a region-specific mediator of the Fgf10/Fgf8 regulatory loop in the limb Ying Liu, Chunqiao Liu, Yoshihiko Yamada, Chen-Ming Fan Author and article information Development (2002) 129 (22): 5289–5300.

指の発生

https://blogs.cuit.columbia.edu/postdocsociety/2023/03/

Figure 1

https://www.nature.com/articles/cdd201311

BMPs are direct triggers of interdigital programmed cell death ...

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Vertebrate limb bud development: moving towards integrative ...

https://www.google.com/url?sa=i&url=https%3A%2F%2Fwww.nature.com%2Farticles%2Fnrg2681&psig=AOvVaw1-txHm7BqoBdO_77zfX8Vu&ust=1733497575697000&source=images&cd=vfe&opi=89978449&ved=2ahUKEwjRlYLr85CKAxX3hVYBHfQmHMQQjhx6BAgAEBo